Thesis
The role of ubiquitylation in regulating apurinic/apyrimidinic endonuclease 1
- Abstract:
-
Apurinic/apyrimidinic endonuclease 1 (APE1) is a key DNA repair factor involved in the DNA base excision repair (BER) pathway that is required for the maintenance of genome stability. In this pathway, APE1 cleaves DNA at an abasic site to generate a DNA single strand break, allowing for repair completion by a DNA polymerase and a DNA ligase. High levels of APE1 have been observed in multiple cancer types however it is not understood if this contributes to cancer onset and development. What...
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Authors
Contributors
+ Dianov, G
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
+ Parsons, J
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:9a6582d4-6fc0-48c9-9c13-6c99e23e66e9
- Local pid:
- ora:8368
- Deposit date:
- 2014-04-29
Terms of use
- Copyright holder:
- Meisenberg, C; Cornelia Meisenberg
- Copyright date:
- 2012
- Notes:
- This thesis is not currently available in ORA.
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