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Journal article

Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D

Abstract:

Coordination of differentiation and cell cycle progression represents an essential process for embryonic development and adult tissue homeostasis. These mechanisms ultimately determine the quantities of specific cell types that are generated. Despite their importance, the precise molecular interplays between cell cycle machinery and master regulators of cell fate choice remain to be fully uncovered. Here, we demonstrate that cell cycle regulators Cyclin D1–3 control cell fate decisions in hum...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1101/gad.271452.115

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Role:
Author
ORCID:
0000-0003-1959-8199
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Role:
Author
ORCID:
0000-0002-4919-9087
British Heart Foundation More from this funder
Cambridge Hospitals National Institute for Health Research Biomedical Research Center More from this funder
Federation of European Biochemical Societies long-term fellowship More from this funder
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Publisher:
Cold Spring Harbor Laboratory Press Publisher's website
Journal:
Genes and Development Journal website
Volume:
30
Issue:
4
Pages:
421-433
Publication date:
2016-02-15
Acceptance date:
2015-12-28
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
Pmid:
26883361
Source identifiers:
822417
Language:
English
Keywords:
Pubs id:
pubs:822417
UUID:
uuid:9a870cd6-4acc-4620-9489-0e7479a81c13
Local pid:
pubs:822417
Deposit date:
2018-06-10

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