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Journal article

Cytosolic processing governs TAP-independent presentation of a critical melanoma antigen

Abstract:

Cancer immunotherapy has been flourishing in recent years with remarkable clinical success. But as more patients are treated, a shadow is emerging that has haunted other cancer therapies: tumors develop resistance. Resistance is often caused by defects in the MHC class I Ag presentation pathway critical for CD8 T cell-mediated tumor clearance. TAP and tapasin, both key players in the pathway, are frequently downregulated in human cancers, correlating with poor patient survival. Reduced depend...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.1701479

Authors


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Role:
Author
ORCID:
0000-0002-2761-2803
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
ORCID:
0000-0002-4995-3270
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Role:
Author
ORCID:
0000-0003-0540-2351
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Role:
Author
ORCID:
0000-0001-6673-8217
Cancer Research Institute More from this funder
Walloon Excellence in Life Sciences and Biotechnology More from this funder
Belgian National Fund for Scientific Research More from this funder
European Union More from this funder
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Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
201
Issue:
6
Pages:
ji1701479
Publication date:
2018-08-22
Acceptance date:
2018-07-26
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pmid:
30135181
Source identifiers:
910664
Language:
English
Keywords:
Pubs id:
pubs:910664
UUID:
uuid:9b211afc-be85-489e-bdc2-512519295b53
Local pid:
pubs:910664
Deposit date:
2018-08-30

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