Journal article
Cytosolic processing governs TAP-independent presentation of a critical melanoma antigen
- Abstract:
-
Cancer immunotherapy has been flourishing in recent years with remarkable clinical success. But as more patients are treated, a shadow is emerging that has haunted other cancer therapies: tumors develop resistance. Resistance is often caused by defects in the MHC class I Ag presentation pathway critical for CD8 T cell-mediated tumor clearance. TAP and tapasin, both key players in the pathway, are frequently downregulated in human cancers, correlating with poor patient survival. Reduced depend...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.4049/jimmunol.1701479
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Authors
Funding
Cancer Research Institute
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Walloon Excellence in Life Sciences and Biotechnology
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Belgian National Fund for Scientific Research
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European Union
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Bibliographic Details
- Publisher:
- American Association of Immunologists Publisher's website
- Journal:
- Journal of Immunology Journal website
- Volume:
- 201
- Issue:
- 6
- Pages:
- ji1701479
- Publication date:
- 2018-08-22
- Acceptance date:
- 2018-07-26
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Pmid:
-
30135181
- Source identifiers:
-
910664
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:910664
- UUID:
-
uuid:9b211afc-be85-489e-bdc2-512519295b53
- Local pid:
- pubs:910664
- Deposit date:
- 2018-08-30
Terms of use
- Copyright date:
- 2018
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