Thesis icon

Thesis

Studies on ribosomal oxygenases

Abstract:

The 2OG oxygenases comprise a superfamily of ferrous iron dependent dioxygenases with multiple biological roles, including in hypoxia sensing, transcriptional control, and splicing control. It was recently proposed that 2OG oxygenases catalyse the hydroxylation of ribosomal proteins in prokaryotes (ycfD) and in humans (NO66 and MINA53), raising the possibility that 2OG oxygenases also control translation. The work described in this thesis concerned investigations on the biochemical and fun...

Expand abstract

Actions


Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Research group:
Prof. Christopher J. Schofield
Oxford college:
St Catherine's College
Role:
Author

Contributors

Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Division:
MPLS
Department:
Chemistry
Role:
Supervisor
More from this funder
Funding agency for:
Sekirnik, R
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:9b8d30f1-7401-48f3-9e60-91d4e515272b
Local pid:
ora:9595
Deposit date:
2014-12-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP