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Journal article

GWAS identifies 14 loci for device-measured physical activity and sleep duration

Abstract:

Physical activity and sleep duration are established risk factors for many diseases, but their aetiology is poorly understood, partly due to relying on self-reported evidence. Here we report a genome-wide association study (GWAS) of device-measured physical activity and sleep duration in 91,105 UK Biobank participants, finding 14 significant loci (7 novel). These loci account for 0.06% of activity and 0.39% of sleep duration variation. Genome-wide estimates of ~ 15% phenotypic variation indic...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-07743-4

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Population Health
Role:
Author
ORCID:
0000-0003-1840-0451
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Cancer Epidemiology Unit
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Big Data Institute
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Statistics
Role:
Author
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Funding agency for:
Doherty, A
Grant:
RE/13/1/30181
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Funding agency for:
Doherty, A
Grant:
RE/13/1/30181
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Funding agency for:
Doherty, A
Grant:
RE/13/1/30181
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Funding agency for:
Holmes, M
Grant:
Intermediate Clinical Research Fellowship (FS/18/23/33512
More from this funder
Funding agency for:
Holmes, M
Grant:
Intermediate Clinical Research Fellowship (FS/18/23/33512
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Article number:
5257
Publication date:
2018-12-10
Acceptance date:
2018-11-22
DOI:
ISSN:
2041-1723
Source identifiers:
949396
Pubs id:
pubs:949396
UUID:
uuid:9b8de35d-513f-4815-b7da-2e0c7e3a18e8
Local pid:
pubs:949396
Deposit date:
2018-12-03

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