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Journal article

Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer.

Abstract:

Emerging data demonstrate homologous recombination (HR) defects in castration-resistant prostate cancers, rendering these tumours sensitive to PARP inhibition. Here we demonstrate a direct requirement for the androgen receptor (AR) to maintain HR gene expression and HR activity in prostate cancer. We show that PARP-mediated repair pathways are upregulated in prostate cancer following androgen-deprivation therapy (ADT). Furthermore, upregulation of PARP activity is essential for the survival o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-017-00393-y

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Role:
Author
ORCID:
0000-0002-2074-5929
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National Institute for Health Research More from this funder
Medical Research Council More from this funder
Cancer Research UK More from this funder
Swedish Research Council More from this funder
Swedish Cancer Society More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Issue:
1
Pages:
374
Publication date:
2017-08-01
Acceptance date:
2017-06-26
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pmid:
28851861
Source identifiers:
726061
Language:
English
Keywords:
Pubs id:
pubs:726061
UUID:
uuid:9b9e6ab4-6547-4bbb-9594-fb454e4ec0ff
Local pid:
pubs:726061
Deposit date:
2018-01-08

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