Journal article
The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins
- Abstract:
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Tick chemokine-binding proteins (evasins) are an emerging class of biologicals that target multiple chemokines and show anti-inflammatory activities in preclinical disease models. Using yeast surface display, we identified a CCL8-binding evasin, P672, from the tick Rhipicephalus pulchellus. We found that P672 binds CCL8 and eight other CC-class chemokines with a Kd < 10 nM and four other CC chemokines with a Kd between 10 and 100 nM and neutralizes CCL3, CCL3L1, and CCL8 with an IC50 < ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(pdf, 5.0MB)
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- Publisher copy:
- 10.1074/jbc.ra117.000487
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Authors
Funding
Saudi Arabian Cultural Bureau
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Bibliographic Details
- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- Journal of Biological Chemistry Journal website
- Volume:
- 293
- Issue:
- 16
- Pages:
- 6134-6146
- Publication date:
- 2018-02-27
- Acceptance date:
- 2018-02-27
- DOI:
- EISSN:
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1083-351X
- ISSN:
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0021-9258
- Pmid:
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29487134
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:827104
- UUID:
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uuid:9bec8460-5b7e-42a3-810e-4b125e613bad
- Local pid:
- pubs:827104
- Deposit date:
- 2018-03-16
Terms of use
- Copyright holder:
- American Society for Biochemistry and Molecular Biology
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 by The American Society for Biochemistry and Molecular Biology, Inc. Final version free via Creative Commons CC-BY license.
- Licence:
- CC Attribution (CC BY)
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