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Journal article

Resistance of transmitted founder HIV-1 to IFITM-mediated restriction

Abstract:

Interferon-induced transmembrane proteins (IFITMs) restrict the entry of diverse enveloped viruses through incompletely understood mechanisms. While IFITMs are reported to inhibit HIV-1, their in vivo relevance is unclear. We show that IFITM sensitivity of HIV-1 strains is determined by the co-receptor usage of the viral envelope glycoproteins as well as IFITM subcellular localization within the target cell. Importantly, we find that transmitted founder HIV-1, which establishes de novo infect...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.chom.2016.08.006

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Grant:
Senior Research Fellowship (WT098049AIA
Publisher:
Cell Press Publisher's website
Journal:
Cell Host and Microbe Journal website
Volume:
20
Issue:
4
Pages:
429–442
Publication date:
2016-09-09
Acceptance date:
2016-08-23
DOI:
EISSN:
1934-6069
ISSN:
1931-3128
Pmid:
27640936
Source identifiers:
645862
Language:
English
Keywords:
Pubs id:
pubs:645862
UUID:
uuid:9c28710c-004d-4aa5-b42e-598538960bcc
Local pid:
pubs:645862
Deposit date:
2016-10-05

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