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Clonal structure of rapid-onset MDV-driven CD4+ lymphomas and responding CD8+ T cells.

Abstract:

Lymphoid oncogenesis is a life threatening complication associated with a number of persistent viral infections (e.g. EBV and HTLV-1 in humans). With many of these infections it is difficult to study their natural history and the dynamics of tumor formation. Marek's Disease Virus (MDV) is a prevalent α-herpesvirus of poultry, inducing CD4+ TCRαβ+ T cell tumors in susceptible hosts. The high penetrance and temporal predictability of tumor induction raises issues related to the clonal structure...

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Journal:
PLoS pathogens
Volume:
7
Issue:
5
Pages:
e1001337
Publication date:
2011-05-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Source identifiers:
203758

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