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Journal article

Cross-reactivity of hepatitis C virus specific vaccine-induced T cells at immunodominant epitopes.

Abstract:

Viral diversity is a challenge to the development of a hepatitis C virus (HCV) vaccine. Following vaccination of humans with adenoviral vectors, we determined the capacity of T cells to target common viral variants at immundominant epitopes ex vivo. We identified two major variants for epitopes NS3(1073) and NS3(1446), and multiple variants for epitope NS3(1406) that occurred in >5% of genotype 1 and 3 sequences at a population level. Cross-reactivity of vaccine-induced T cells was determi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/eji.201444686

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Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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More from this funder
Funding agency for:
Salio, M
Grant:
C399/A2291
James Martin School for 21st Century More from this funder
Medical Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
Wiley Publisher's website
Journal:
European journal of immunology Journal website
Volume:
45
Issue:
1
Pages:
309-316
Publication date:
2015-01-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Source identifiers:
485349

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