A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction
INTRODUCTION: Genome Wide Association studies have consistently identified an association between coronary artery disease (CAD) and a locus on chromosome 10 containing a single gene, JCAD (formerly KIAA1462). However, little is known about the mechanism by which JCAD could influence the development of atherosclerosis.
METHODS AND RESULTS: Vascular function was quantified in subjects with CAD by flow mediated dilatation [FMD] and vasorelaxation respo...Expand abstract
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- Peer review status:
- Peer reviewed
- Copyright holder:
- Douglas et al
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- © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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