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The analysis of DNA interstrand cross-links and their repair by the modified comet assay

Abstract:

DNA interstrand cross-links (ICLs) are an extremely toxic form of DNA damage that cells experience upon exposure to natural metabolites. Moreover, ICLs are cytotoxic lesions produced by a range of clinically important anticancer agents. Therefore, improving our understanding of ICL induction and processing has important implications in biology and medicine. The sensitive detection of ICLs in mammalian cells is challenging but has been aided by the development of a modified form of the single-...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/978-1-0716-0323-9_7

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Oxford college:
University College
Role:
Author
ORCID:
0000-0002-8679-4627

Contributors

Role:
Editor
Publisher:
Humana Press Publisher's website
Pages:
79-88
Series:
Methods in Molecular Biology
Series number:
2119
Host title:
DNA Electrophoresis: Methods and Protocols
Chapter number:
7
Place of publication:
New York
Publication date:
2020-01-28
DOI:
EISBN:
9781071603239
EISSN:
1940-6029
ISSN:
1064-3745
Source identifiers:
1076053
ISBN:
9781071603222
Language:
English
Keywords:
Pubs id:
pubs:1076053
UUID:
uuid:9d840e3f-f760-4b78-86c9-3dab390164d9
Local pid:
pubs:1076053
Deposit date:
2019-12-03

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