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High-multiplicity HIV-1 infection and neutralizing antibody evasion mediated by the macrophage-T cell virological synapse

Abstract:

Macrophage infection is considered to play an important role in HIV-1 pathogenesis and persistence. Using a primary cell-based coculture model, we show that monocyte-derived macrophages (MDM) efficiently transmit a high-multiplicity HIV-1 infection to autologous CD4(+) T cells through a viral envelope glycoprotein (Env) receptor- and actin-dependent virological synapse (VS), facilitated by interactions between ICAM-1 and LFA-1. Virological synapse (VS)-mediated transmission by MDM results in ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/JVI.03245-13

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Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of virology Journal website
Volume:
88
Issue:
4
Pages:
2025-2034
Publication date:
2014-02-01
Acceptance date:
2013-11-26
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Source identifiers:
441602

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