Journal article
High-multiplicity HIV-1 infection and neutralizing antibody evasion mediated by the macrophage-T cell virological synapse
- Abstract:
-
Macrophage infection is considered to play an important role in HIV-1 pathogenesis and persistence. Using a primary cell-based coculture model, we show that monocyte-derived macrophages (MDM) efficiently transmit a high-multiplicity HIV-1 infection to autologous CD4(+) T cells through a viral envelope glycoprotein (Env) receptor- and actin-dependent virological synapse (VS), facilitated by interactions between ICAM-1 and LFA-1. Virological synapse (VS)-mediated transmission by MDM results in ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 1.3MB)
-
- Publisher copy:
- 10.1128/JVI.03245-13
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Bibliographic Details
- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Journal of virology Journal website
- Volume:
- 88
- Issue:
- 4
- Pages:
- 2025-2034
- Publication date:
- 2014-02-01
- Acceptance date:
- 2013-11-26
- DOI:
- EISSN:
-
1098-5514
- ISSN:
-
0022-538X
- Source identifiers:
-
441602
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:441602
- UUID:
-
uuid:9dd36531-3f51-4d6d-82cc-13241671c1d5
- Local pid:
- pubs:441602
- Deposit date:
- 2014-02-13
Terms of use
- Copyright holder:
- American Society for Microbiology
- Copyright date:
- 2014
- Notes:
- This journal article was published by The American Society for Microbiology in Journal of Virology on 2013-12-04, available online: http://dx.doi.org/10.1128/JVI.03245-13
If you are the owner of this record, you can report an update to it here: Report update to this record