Journal article icon

Journal article

Targeting prolyl-tRNA synthetase to accelerate drug discovery against malaria, leishmaniasis, toxoplasmosis, cryptosporidiosis, and coccidiosis.

Abstract:

Developing anti-parasitic lead compounds that act on key vulnerabilities are necessary for new anti-infectives. Malaria, leishmaniasis, toxoplasmosis, cryptosporidiosis and coccidiosis together kill >500,000 humans annually. Their causative parasites Plasmodium, Leishmania, Toxoplasma, Cryptosporidium and Eimeria display high conservation in many housekeeping genes, suggesting that these parasites can be attacked by targeting invariant essential proteins. Here, we describe selective and po...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1016/j.str.2017.07.015

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
Expand authors...
Indian Department of Biotechnology More from this funder
Japanese Ministry of Education, Culture, Sports, Science and Technology More from this funder
Indian Department of Science and Technology, More from this funder
Bill and Melinda Gates Foundation. More from this funder
Expand funders...
Publisher:
Elsevier Publisher's website
Journal:
Structure Journal website
Volume:
25
Issue:
10
Pages:
1495-1505.e6
Publication date:
2017-08-31
Acceptance date:
2017-07-26
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Pmid:
28867614
Source identifiers:
726015
Language:
English
Keywords:
Pubs id:
pubs:726015
UUID:
uuid:9df1f8a5-bd4e-4b5e-b0f8-764393cecb81
Local pid:
pubs:726015
Deposit date:
2017-09-28

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP