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Thesis

Single molecule studies of F1-ATPase and the application of external torque

Abstract:

F1-ATPase, the sector of ATP synthase where the synthesis of cellular ATP occurs, is a rotary molecular motor in its own right. Driven by ATP hydrolysis, direct observation of the rotation of the central axis within single molecules of F1 is possible. Operating at close to 100% efficiency, F1 from thermophilic Bacillus has been shown to produce ~40pN˙nm of torque during rotation.

This thesis details the groundwork required for the di...

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Institution:
University of Oxford
Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Research group:
Molecular Motors Group - Dr Richard M Berry
Oxford college:
Balliol College
Role:
Author

Contributors

Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Role:
Supervisor
Publication date:
2009
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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