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Thesis

Investigating the contribution of the unfolded protein response to prostate cancer bone metastasis

Abstract:

The majority of deaths from prostate cancer (PCa) arise following metastasis, particularly to the skeleton. ER stress and the unfolded protein response (UPR) promote primary PCa, however, the contribution of the UPR to PCa bone metastasis remains unknown. The aim of this work was to determine the role of the UPR in PCa bone metastasis, focusing on the osteogenic potential of PCa cells, epithelial to mesenchymal transition (EMT) and migration, and PCa-induced bone disease. Using paired androge...

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Division:
MSD
Department:
Surgical Sciences
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Research group:
Bone oncology group
Oxford college:
St Edmund Hall
Role:
Supervisor
ORCID:
0000-0002-1257-5659
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Supervisor
ORCID:
0000-0003-1889-6530
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Supervisor
ORCID:
0000-0001-5347-5083
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Supervisor
ORCID:
0000-0002-0474-1207
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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