Journal article
Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.
- Abstract:
-
The mechanosensitive two-pore domain (K2P) K(+) channels (TREK-1, TREK-2, and TRAAK) are important for mechanical and thermal nociception. However, the mechanisms underlying their gating by membrane stretch remain controversial. Here we use molecular dynamics simulations to examine their behavior in a lipid bilayer. We show that TREK-2 moves from the "down" to "up" conformation in direct response to membrane stretch, and examine the role of the transmembrane pressure profile in this process. ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(pdf, 3.8MB)
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- Publisher copy:
- 10.1016/j.str.2017.03.006
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Authors
Funding
Wellcome Trust
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Biotechnology and Biological Sciences Research Council
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Deutsche Forschungsgemeinschaft
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Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Structure Journal website
- Publication date:
- 2017-04-06
- Acceptance date:
- 2017-03-10
- DOI:
- EISSN:
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1878-4186
- ISSN:
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0969-2126
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:679828
- UUID:
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uuid:a02f3096-8f94-4642-89ac-0a4a4aa1675f
- Local pid:
- pubs:679828
- Deposit date:
- 2017-04-12
Terms of use
- Copyright holder:
- Aryal et al
- Copyright date:
- 2017
- Notes:
- © 2017 the Author(s). Published by Elsevier Ltd (Cell Press). Open Access funded by Wellcome Trust, available under a Creative Commons CC-BY 4.0 license.
- Licence:
- CC Attribution (CC BY)
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