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Journal article

Depletion of the type 1 IGF receptor delays repair of radiation-induced DNA double strand breaks

Abstract:

Background and purpose:

IGF-1R depletion sensitizes prostate cancer cells to ionizing radiation and DNAdamaging cytotoxic drugs. This study investigated the hypothesis that IGF-1R regulates DNA double strand break (DSB) repair.

Methods:

We tested effects of IGF-1R siRNA transfection on the repair of radiation-induced DSBs by immunoblotting and immunofluorescence for cH2AX, and pulsed-field gel electrophoresis. Homologous recombination (HR) was quantified by reporte...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.radonc.2012.03.009

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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National Institute of Health Research More from this funder
Medical Research Council More from this funder
Prostate Action More from this funder
British Urological Foundation More from this funder
Higher Education Funding Council for England More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Radiotherapy and Oncology Journal website
Volume:
103
Issue:
3
Pages:
402-409
Publication date:
2012-06-01
Acceptance date:
2012-03-14
DOI:
EISSN:
1879-0887
ISSN:
0167-8140
Source identifiers:
329062

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