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High level antibody response to pandemic influenza H1N1/09 virus is associated with interferon-induced transmembrane protein-3 rs12252-CC in young adults

Abstract:
Background: The C allele of the interferon-induced transmembrane protein-3 (IFITM3) SNP rs12252, a common allele in South East Asia and China, is strongly associated with severe influenza infection. However, despite the high occurrence of rs12252-CC genotype in Chinese population (~25%), severe influenza infection is rare. The aim of study is to determine whether rs12252-CC individuals have pre-existing antibody responses to previous seasonal influenza infections. Coh... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fcimb.2018.00134

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Cellular and Infection Microbiology Journal website
Volume:
8
Article number:
134
Publication date:
2018-05-15
Acceptance date:
2018-04-18
DOI:
ISSN:
2235-2988
Source identifiers:
842206
Keywords:
Pubs id:
pubs:842206
UUID:
uuid:a09795a7-6e2b-404d-b7b4-36f4628c8b6f
Local pid:
pubs:842206
Deposit date:
2018-04-18

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