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Journal article : Review

Distinct metabolic pathways mediate regulatory T cell differentiation and function

Abstract:

Investigation of the cellular metabolic pathways of immune cells, or immunometabolism, is a field of increasing interest. An understanding of immunometabolism provides routes to modifying T cell function for therapeutic purposes. Here, we review immunometabolism with a specific focus on regulatory T cells (Tregs). While T cells are known to switch their metabolic profile from oxidative phosphorylation to aerobic glycolysis upon activation, in vitro-induced Tregs display alternate metabolic ch...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.imlet.2020.04.011

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Oxford college:
Wolfson College
Role:
Author
More by this author
Role:
Author
ORCID:
0000-0002-6232-5295
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
Surgical Sciences
Oxford college:
Exeter College
Role:
Author
ORCID:
0000-0002-8279-7732
Department of Health More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Immunology Letters Journal website
Volume:
223
Pages:
53-61
Publication date:
2020-04-28
Acceptance date:
2020-04-18
DOI:
EISSN:
1879-0542
ISSN:
0165-2478
Pmid:
32360534
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1104179
Local pid:
pubs:1104179
Deposit date:
2021-04-19

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