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Thesis

Chiral cation-directed asymmetric 5-endo-trig cyclizations

Abstract:

The primary objective of this research project was to develop a novel protocol for the synthesis of densely functionalized optically enriched indanes through a chiral cation directed 5-endo-trig ring closure. In chapter two, a convergent strategy for the construction of the cyclization precursors is reported, which employs two easily adapted fragments. In chapter three, a range of quaternary ammonium salts are screened to establish the optimal phase-transfer conditions for this system. A v...

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  • (Dissemination version, pdf, 9.0MB)

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
Dr Martin D. Smith
Oxford college:
St Catherine's College
Role:
Author

Contributors

Division:
MPLS
Department:
Chemistry
Role:
Supervisor
More from this funder
Funding agency for:
Johnston, CP
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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