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Thesis

Modulation of the hypoxic response in cancer; inhibition of the HIF-1α/p300 protein-protein interaction

Abstract:

Hypoxia inducible factor (HIF)-1α is a heterodimerically-activated transcription factor central to the cellular response to hypoxic environments and is often upregulated in cancer. Binding of HIF-1α to the co-activator p300 is necessary for the hypoxia-induced transcription of many oncogenic proteins. The aim of this project was to develop novel small molecule inhibitors of the HIF-1α/p300 protein-protein interaction (PPI).

Initial work focused on designing, validating and optimisin...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
Hamilton and Schofield Groups
Oxford college:
St John's College
Role:
Author

Contributors

Division:
MPLS
Department:
History Faculty
Sub department:
Archaeology Research Lab
Role:
Supervisor
Division:
MPLS
Department:
History Faculty
Sub department:
Archaeology Research Lab
Role:
Supervisor
More from this funder
Funding agency for:
Jayatunga, M
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:a3ae9d39-f7cc-4ba5-b921-2a7855ee1512
Local pid:
ora:10481
Deposit date:
2015-03-10

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