Journal article
Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion
- Abstract:
-
Background
Indoleamine 2,3-dioxygenase (IDO), the first step in the kynurenine pathway (KP), is upregulated in some cancers and represents an attractive therapeutic target given its role in tumour immune evasion. However, the recent failure of an IDO inhibitor in a late phase trial raises questions about this strategy.
Methods
Matched renal cell carcinoma (RCC) and normal kidney tissues were subject to proteomic profiling. Tissue immu...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Cancer Research UK
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- British Journal of Cancer Journal website
- Volume:
- 123
- Issue:
- 1
- Pages:
- 137-147
- Publication date:
- 2020-05-11
- Acceptance date:
- 2020-04-15
- DOI:
- EISSN:
-
1532-1827
- ISSN:
-
0007-0920
- Pmid:
-
32390008
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1104932
- Local pid:
- pubs:1104932
- Deposit date:
- 2020-08-20
Terms of use
- Copyright holder:
- Hornigold, N et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s), under exclusive licence to Cancer Research UK 2020.
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