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Journal article

Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion

Abstract:

Background

Indoleamine 2,3-dioxygenase (IDO), the first step in the kynurenine pathway (KP), is upregulated in some cancers and represents an attractive therapeutic target given its role in tumour immune evasion. However, the recent failure of an IDO inhibitor in a late phase trial raises questions about this strategy.

Methods

Matched renal cell carcinoma (RCC) and normal kidney tissues were subject to proteomic profiling. Tissue immu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41416-020-0874-y

Authors


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Cancer Research UK More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
British Journal of Cancer Journal website
Volume:
123
Issue:
1
Pages:
137-147
Publication date:
2020-05-11
Acceptance date:
2020-04-15
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Pmid:
32390008
Language:
English
Keywords:
Pubs id:
1104932
Local pid:
pubs:1104932
Deposit date:
2020-08-20

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