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Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection.

Abstract:

Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking. Here we demonstrate positive selection of HIV-1 proviral sequences encoding variants within a CTL epitope in Nef, a gene product critical for viral pathogenicity, during and after seroconversion. These positively selected HIV-1 variants carried epitope sequence changes that either diminished or escaped CTL recogniti...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.94.5.1890

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
94
Issue:
5
Pages:
1890-1895
Publication date:
1997-03-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
19923

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