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Nitric oxide modulates metabolic remodelling in inflammatory macrophages through TCA cycle regulation and itaconate accumulation

Abstract:

Classical activation of macrophages (M(LPS+IFNγ)) elicits the expression of inducible nitric oxide synthase (iNOS), generating large amounts of NO and inhibiting mitochondrial respiration. Upregulation of glycolysis and a disrupted tricarboxylic acid (TCA) cycle underpin this switch to a pro-inflammatory phenotype. We show that the NOS cofactor tetrahydrobiopterin (BH4) modulates IL-1β production and key aspects of metabolic remodeling in activated murine macrophages via NO production. Using ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2019.06.018

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
28
Issue:
1
Pages:
218-230
Publication date:
2019-07-02
Acceptance date:
2019-06-05
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Source identifiers:
1010281
Keywords:
Pubs id:
pubs:1010281
UUID:
uuid:a4d0132d-cdbd-49a9-9a02-0e9f6cac443d
Local pid:
pubs:1010281
Deposit date:
2019-06-10

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