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Journal article

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

Abstract:

Lymphatic vessels develop from specialized endothelial cells in preexisting blood vessels, but the molecular signals that regulate this separation are unknown. Here we identify a failure to separate emerging lymphatic vessels from blood vessels in mice lacking the hematopoietic signaling protein SLP-76 or Syk. Blood-lymphatic connections lead to embryonic hemorrhage and arteriovenous shunting. Expression of slp-76 could not be detected in endothelial cells, and blood-filled lymphatics also ar...

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Publication status:
Published

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Publisher copy:
10.1126/science.1079477

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Journal:
Science (New York, N.Y.)
Volume:
299
Issue:
5604
Pages:
247-251
Publication date:
2003-01-01
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Source identifiers:
102753

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