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Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.

Abstract:

The TREK subfamily of two-pore domain (K2P) K(+) channels exhibit polymodal gating by a wide range of physical and chemical stimuli. Crystal structures now exist for these channels in two main states referred to as the "up" and "down" conformations. However, recent studies have resulted in contradictory and mutually exclusive conclusions about the functional (i.e., conductive) status of these two conformations. To address this problem, we have used the state-dependent TREK-2 inhibitor norfluo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1085/jgp.201611601

Authors


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Role:
Author
ORCID:
0000-0002-0859-3854
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Genomics Consortium
Role:
Author
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Wellcome Trust More from this funder
German Research Foundation More from this funder
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of General Physiology Journal website
Volume:
147
Issue:
6
Pages:
497-505
Publication date:
2016-05-01
Acceptance date:
2016-05-09
DOI:
EISSN:
1540-7748
ISSN:
0022-1295
Pmid:
27241700
Source identifiers:
625393
Language:
English
Keywords:
Pubs id:
pubs:625393
UUID:
uuid:a609ef5a-ea28-4658-a668-e396b0836ab0
Local pid:
pubs:625393
Deposit date:
2018-03-26

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