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Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles

Abstract:

Among the various host cellular processes that are hijacked by flaviviruses, few mechanisms have been described with regard to viral egress. Here we investigate how flaviviruses exploit Src family kinases (SFKs) for exit from infected cells. We identify Lyn as a critical component for secretion of Dengue and Zika infectious particles and their corresponding virus like particles (VLPs). Pharmacological inhibition or genetic depletion of the SFKs, Lyn in particular, block virus secretion. Lyn−/...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-020-19028-w

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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
11
Issue:
1
Article number:
5189
Publication date:
2020-10-15
Acceptance date:
2020-09-25
DOI:
EISSN:
2041-1723
Pmid:
33060596

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