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Journal article

Macrophage infection via selective capture of HIV-1-infected CD4+ T cells.

Abstract:

Macrophages contribute to HIV-1 pathogenesis by forming a viral reservoir and mediating neurological disorders. Cell-free HIV-1 infection of macrophages is inefficient, in part due to low plasma membrane expression of viral entry receptors. We find that macrophages selectively capture and engulf HIV-1-infected CD4+ T cells leading to efficient macrophage infection. Infected T cells, both healthy and dead or dying, were taken up through viral envelope glycoprotein-receptor-independent interact...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.chom.2014.10.010

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Cell host and microbe Journal website
Volume:
16
Issue:
6
Pages:
711-721
Publication date:
2014-11-20
Acceptance date:
2014-10-14
DOI:
EISSN:
1934-6069
ISSN:
1931-3128
Source identifiers:
493167
Language:
English
Keywords:
Pubs id:
pubs:493167
UUID:
uuid:a6590af1-24aa-45fa-a39d-2f98d5e84397
Local pid:
pubs:493167
Deposit date:
2014-12-19

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