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Thesis

Structure and function of bacterial proteins secreted by the type three secretion and twin arginine translocation pathways

Abstract:

The Type Three Secretion Systems (T3SSs) of Gram-negative bacteria, including Shigella, Salmonella, and Enteropathogenic/Enterohaemorrhagic Escherichia coli (EPEC/EHEC), pass virulence factors directly into the host to mediate invasion. Prior to secretion down the narrow T3SS channel, effector proteins associate with chaperone proteins. The binding enables the T3SS to keep effectors soluble and partially unfolded for secretion. In the first part of this thesis, the association of one promi...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:a69f34ac-0edc-4c27-961b-d1638c6d51b3
Local pid:
ora:7716
Deposit date:
2014-02-03

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