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Journal article

The cardiac sympathetic co-transmitter neuropeptide Y is pro-arrhythmic following ST-elevation myocardial infarction despite beta-blockade

Abstract:

AIMS:ST-elevation myocardial infarction is associated with high levels of cardiac sympathetic drive and release of the co-transmitter neuropeptide Y (NPY). We hypothesized that despite beta-blockade, NPY promotes arrhythmogenesis via ventricular myocyte receptors. METHODS AND RESULTS:In 78 patients treated with primary percutaneous coronary intervention, sustained ventricular tachycardia (VT) or fibrillation (VF) occurred in 6 (7.7%) within 48 h. These patients had significantly (P < 0.05)...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/eurheartj/ehz852

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Publisher:
Oxford University Press Publisher's website
Journal:
European Heart Journal Journal website
Volume:
41
Issue:
23
Pages:
2168-2179
Publication date:
2019-12-13
Acceptance date:
2019-11-12
DOI:
EISSN:
1522-9645
ISSN:
0195-668X
Pmid:
31834357
Source identifiers:
1077950
Language:
English
Keywords:
Pubs id:
pubs:1077950
UUID:
uuid:a77d8660-557c-4a21-8028-78fb488a2b4f
Local pid:
pubs:1077950
Deposit date:
2019-12-16

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