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Working paper

Artificial antigen presenting cells for detection and desensitisation of auto-reactive T cells associated with type 1 diabetes

Abstract:

Autoimmune diseases and in particular type 1 diabetes rely heavily on treatments that target the symptoms rather than prevent the underlying disease. One of the barriers to better therapeutic strategies is the inability to detect and efficiently target rare autoreactive T-cell populations that are major drivers of these conditions. Here, we develop a unique artificial antigen presenting cell (aAPC) system from biocompatible polymer particles that allows specific encapsulation of bioactive ing...

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Publication status:
Published
Peer review status:
Not peer reviewed

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Publisher copy:
10.1101/2020.12.26.424333

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Role:
Author
ORCID:
0000-0001-5033-8171
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Publication date:
2020-12-27
DOI:
Language:
English
Keywords:
Pubs id:
1025148
Local pid:
pubs:1025148
Deposit date:
2021-11-28

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