Journal article
Niacin induces PPARγ expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways
- Abstract:
-
HM74 and HM74a have been identified as receptors for niacin. HM74a mediates the pharmacological anti-lipolytic effects of niacin in adipocytes by reducing intracellular cyclic AMP (cAMP) and inhibiting release of free fatty acids into the circulation. In macrophages, niacin induces peroxisome proliferator-activated receptor γ (PPARγ)-dependent and cAMP-dependent expression of genes mediating reverse cholesterol transport, although via an unidentified receptor. We describe constitutive express...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Cancer Research UK
More from this funder
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Biochemical Pharmacology Journal website
- Volume:
- 71
- Issue:
- 5
- Pages:
- 646-656
- Publication date:
- 2006-02-01
- DOI:
- ISSN:
-
0006-2952
Item Description
- Language:
- English
- Subjects:
- UUID:
-
uuid:a8a5ce26-1079-4f70-878a-ee1cc2aa6ca5
- Local pid:
- ora:6313
- Deposit date:
- 2012-06-27
Related Items
Terms of use
- Copyright holder:
- Elsevier Inc
- Copyright date:
- 2005
- Notes:
- The full-text of this article is not currently available in ORA, but you may be able to access the article via the publisher copy link on this record page.
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record