Thesis
Protein complexes in the gas phase: structural insights from ion mobility-mass spectrometry and computational modelling
- Abstract:
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Structure determination of macromolecular protein assemblies remains a challenge for well-established experimental methods. In this thesis, an emerging structural technique, ion mobility-mass spectrometry (IM-MS) is explored. An assessment of collision cross section (CCS) measurement accuracy using travelling-wave IM (TWIMS) instrumentation was carried out (Chapter 3). Through the collation of a protein complex CCS database and the development of a calibration framework for TWIMS, signific...
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Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:a958f616-e37f-42e2-bf57-a38d58388b0c
- Local pid:
- ora:7527
- Deposit date:
- 2013-10-29
Terms of use
- Copyright holder:
- Zoe Hall
- Copyright date:
- 2013
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