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Working paper

A single cycle influenza virus coated in H7 hemagglutinin provides heterotypic protection and neutralising antibody responses to both glycoproteins

Abstract:

A non-replicating form of pseudotyped influenza virus, inactivated by suppression of the hemagglutinin signal sequence (S-FLU), can act as a broadly protective vaccine. S-FLU can infect for a single round only, and induces heterotypic protection predominantly through activation of cross-reactive T cells in the lung. Unlike the licensed live attenuated virus, it cannot reassort a pandemic HA into seasonal influenza. Here we present data on four new forms of S-FLU coated with the H7 hemagglutin...

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Publication status:
Not published
Peer review status:
Not peer reviewed

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Publisher copy:
10.1101/224550

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
ORCID:
0000-0002-9208-674X
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Institution:
University of Oxford
Division:
Medical Sciences
Department:
RDM Investigative Medicine Division
Role:
Author
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Institution:
University of Oxford
Oxford college:
Green Templeton College
Role:
Author
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Medical Research Council More from this funder
Oxford University More from this funder
Series:
Biorxiv
Host title:
Biorxiv
Publication date:
2017-11-27
Acceptance date:
2017-11-27
DOI:
Source identifiers:
896595
Keywords:
Pubs id:
pubs:896595
UUID:
uuid:a96e2d01-53e4-4ca9-9209-96e76989b1c1
Local pid:
pubs:896595
Deposit date:
2018-08-20

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