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Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel

Abstract:

Two-pore domain (K2P) K+ channels have many important physiological functions. However, the functional properties of the TWIK-1 (K2P1.1/KCNK1) K2P channel remain poorly characterized because heterologous expression of this ion channel yields only very low levels of functional activity. Several underlying reasons have been proposed, including TWIK-1 retention in intracellular organelles, inhibition by post-translational sumoylation, a hydrophobic barrier within the pore, and a low open probabi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.ra119.010612

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Role:
Author
ORCID:
0000-0002-6192-5651
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Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
295
Issue:
2
Pages:
610–618
Publication date:
2019-12-05
Acceptance date:
2019-12-04
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pmid:
31806709
Source identifiers:
1077225
Language:
English
Keywords:
Pubs id:
pubs:1077225
UUID:
uuid:a9dfcbe5-5d4b-4ef6-8a3c-50435345ac25
Local pid:
pubs:1077225
Deposit date:
2019-12-27

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