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Thesis

The role of PARPs and APLF in DNA interstrand crosslink repair

Abstract:

Over the duration of every organism’s life its cells continuously face insults to their DNA. The accumulation of lesions results in cell death, inflammation and, following the activation of oncogenes or inactivating mutations of DNA repair factors, cancer formation. One particularly deleterious form of DNA damage are DNA interstrand crosslinks (ICLs), which prevent DNA strand seperation, therefore interfering with replication and transcription. Here we uncover a novel function for PARPs an...

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Institution:
University of Oxford
Oxford college:
St Catherine's College
Role:
Author

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Institution:
University of Oxford
Oxford college:
St Peter's College
Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
UUID:
uuid:aa5c26ba-705d-4f5d-87e1-9479fe37a51b
Deposit date:
2018-04-23

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