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A novel role for triglyceride metabolism in foxp3 expression

Abstract:

Lipid metabolism plays a key role in many cellular processes. We show here that regulatory T cells have enhanced lipid storage within subcellular lipid droplets (LD). They also express elevated amounts of both isoforms of diacylglycerol acyl transferase (DGAT1 & 2), enzymes required for the terminal step of triacylglycerol synthesis. In regulatory T-cells (Tregs), the conversion of diacylglycerols to triacylglycerols serves two additional purposes other than lipid storage. First, we demon...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2019.01860

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
ORCID:
0000-0002-8160-2446
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology
Volume:
10
Pages:
1860
Publication date:
2019-08-13
Acceptance date:
2019-07-23
DOI:
ISSN:
1664-3224
Pmid:
31456800
Source identifiers:
1048612
Language:
English
Keywords:
Pubs id:
pubs:1048612
UUID:
uuid:aa620a2d-b871-46e8-9236-ceefe4744768
Local pid:
pubs:1048612
Deposit date:
2019-09-03

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