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Thesis

Signal transduction of the GPCR Smoothened: a key protein in Hedgehog-regulated morphogenesis and oncogenesis

Abstract:

The Hedgehog signalling pathway is crucial for embryonic development and tissue homeostasis. Misregulation can result in severe developmental defects or oncogenesis, with an estimated 25% of all cancer deaths exhibiting improper Hedgehog signalling. The G-protein coupled receptor Smoothened plays a vital role in this pathway; it is responsible for transducing the Hedgehog signal across the plasma membrane. This makes Smoothened a highly attractive target for anticancer drug development. Despi...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Oxford college:
Green Templeton College
Role:
Author

Contributors

Role:
Supervisor
ORCID:
0000-0002-6635-3621
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Funding agency for:
Woolley, R
Grant:
203726/Z/16/Z
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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