Thesis
Identification and functional analysis of single nucleotide polymorphisms that affect human cancer
- Abstract:
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Aims: The p53 regulatory network is crucial in directing the suppression of cancer formation and mediating the response to commonly used cancer therapies. Functional genetic variants in the genes comprising this network could help identify individuals at greater risk for cancer and patients with poorer responses to therapies, but few such variants have been identified as yet. Methods: We first develop and apply three different screens that utilize known characteristics of functional single nu...
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Bibliographic Details
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:aacc7084-81a8-4e97-b1ac-024d9bed106e
- Local pid:
- ora:8718
- Deposit date:
- 2014-07-04
Terms of use
- Copyright holder:
- Grochola, L
- Copyright date:
- 2011
- Notes:
- This thesis is not currently available via ORA.
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