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Autocrine IFNγ controls the regulatory function of lymphoproliferative double negative T cells.

Abstract:

TCRαβ(+) CD4(-)CD8(-)NK(-) double negative T cells (DN T cells) can act as regulatory T cells to inhibit allograft rejection and autoimmunity. Their role in graft-versus-host disease and mechanisms of suppression remain elusive. In this study, we demonstrate that DN T cells can inhibit CD4(+) T cell-mediated GVHD in a semi-allogeneic model of bone marrow transplantation. Furthermore, we present evidence of a novel autocrine IFNγ signaling pathway in Fas-deficient C57BL/6.lpr (B6.lpr) DN T cel...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0047732

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
7
Issue:
10
Pages:
e47732
Publication date:
2012-10-15
Acceptance date:
2012-09-14
DOI:
EISSN:
1932-6203
Source identifiers:
400589

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