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Dual RNA-seq of Orientia tsutsugamushi informs on host-pathogen interactions for this neglected intracellular human pathogen

Abstract:

Studying emerging or neglected pathogens is often challenging due to insufficient information and absence of genetic tools. Dual RNA-seq provides insights into host-pathogen interactions, and is particularly informative for intracellular organisms. Here we apply dual RNA-seq to Orientia tsutsugamushi (Ot), an obligate intracellular bacterium that causes the vector-borne human disease scrub typhus. Half the Ot genome is composed of repetitive DNA, and there is minimal collinearity in gene orde...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-020-17094-8

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Role:
Author
ORCID:
0000-0003-1014-4609
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
11
Issue:
1
Article number:
3363
Publication date:
2020-07-03
Acceptance date:
2020-06-11
DOI:
EISSN:
2041-1723
Pmid:
32620750

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