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Binding of monoclonal anti-interleukin 2 antibody to nucleoli in acute leukemia blast cells.

Abstract:

Neutralizing anti-IL-2, anti-IL-3, and anti-IL-6 monoclonal antibodies (MAbs) were used for the immunoenzymatic detection of the respective cytokines in blast cells of 38 patients with acute myeloid (AML) and lymphoid (ALL) leukemias by the APAAP-technique. In 20/24 AML-cases (83%) blast cells showed intranuclear staining with MAb anti-IL-2 (DMS-1). In 17 cases reaction was restricted to the nucleoli, in 4 cases additional cytoplasmic staining was observed. Only 2/13 (15%) of the ALL cases sh...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Leukemia research
Volume:
16
Issue:
6-7
Pages:
589-595
Publication date:
1992-06-01
DOI:
EISSN:
1873-5835
ISSN:
0145-2126
Source identifiers:
396459

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