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Thesis

Chromatin regulation of lifespan in C. elegans

Abstract:

The biological basis of lifespan regulation is a subject of intense interest, and epigenetic control of gene expression is thought to play an important role in the ageing process. A library of RNAi clones against chromatin factors was used to screen for their effects on lifespan in C.elegans, utilising microscopic examination of lipofuscin accumulation as a primary biomarker of ageing. A secondary RNAi screen involving full lifespan monitoring confirmed knock-downs of four genes, ...

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Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Role:
Author

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Institution:
University of Oxford
Oxford college:
Hertford College
Role:
Supervisor
Role:
Supervisor
Wellcome Trust More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:ac80efde-7588-48e8-844c-26961e86bda4
Deposit date:
2016-09-20

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