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Thesis

Proteomics and Transcriptomics of the Betz cell in the Human Brain.

Abstract:

Very little is known about the enigmatic gigantopyramidal neuron in the Primary Motor Cortex. These Betz cells are the largest neurons in the human brain, display unique morphology, play a fundamental role in voluntary movement, and are selectively vulnerable to a range of neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS). Yet, there has been no targeted studies to investigate the molecular profile of these neurons and how that may be affected in disease. Here, for ...

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Division:
MSD
Department:
Clinical Neurosciences
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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