Journal article
Fine mapping genetic determinants of the highly variably expressed MHC gene ZFP57.
- Abstract:
-
ZFP57 is an important transcriptional regulator involved in DNA methylation and genomic imprinting during development. Here we demonstrate that gene expression also occurs at a low level in adult peripheral blood cells and other tissues including the kidney and thymus, but is critically dependent on underlying local genetic variation within the MHC. We resolve a highly significant expression quantitative trait locus for ZFP57 involving single-nucleotide polymorphisms (SNPs) in the first intro...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/ejhg.2013.244
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Authors
Bibliographic Details
- Journal:
- European journal of human genetics : EJHG
- Volume:
- 22
- Issue:
- 4
- Pages:
- 568-571
- Publication date:
- 2014-04-01
- DOI:
- EISSN:
-
1476-5438
- ISSN:
-
1018-4813
- Source identifiers:
-
436937
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:436937
- UUID:
-
uuid:aca5c2e2-cfbb-45e7-91bf-6e7c38bb12f2
- Local pid:
- pubs:436937
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2014
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