Journal article icon

Journal article

Fine mapping genetic determinants of the highly variably expressed MHC gene ZFP57.

Abstract:

ZFP57 is an important transcriptional regulator involved in DNA methylation and genomic imprinting during development. Here we demonstrate that gene expression also occurs at a low level in adult peripheral blood cells and other tissues including the kidney and thymus, but is critically dependent on underlying local genetic variation within the MHC. We resolve a highly significant expression quantitative trait locus for ZFP57 involving single-nucleotide polymorphisms (SNPs) in the first intro...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/ejhg.2013.244

Authors


Expand authors...
Journal:
European journal of human genetics : EJHG
Volume:
22
Issue:
4
Pages:
568-571
Publication date:
2014-04-01
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
Source identifiers:
436937

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP