Dataset
Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package
- Documentation:
-
A description of the materials and methods is included within the TEP datasheet. This work provides the early tools to develop substrate reduction inhibitors for a genetic childhood seizure disorder, with the hypothesis to target the enzyme (AASS) upstream of the defective gene (ALDH7A1) in the human lysine metabolic pathway. This TEP package includes recombinant human AASS purification protocols, structures of the AASS second domain in different states, in vitro assays to detect ligand bindi...
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- Version:
- 1
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Authors/Creators
Contributors
+ Yue, W
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Principal Investigator (PI)
+ Rembeza, E
Role:
Researcher
+ Arruda, P
Role:
Researcher
+ Pena, I
Role:
Researcher
+ McLaughlin, M
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Researcher
Funding
Bibliographic Details
- Publisher:
- University of Oxford
- Publication date:
- 2018
- Version number:
- 1
- DOI:
Item Description
- Keywords:
- Subjects:
- UUID:
-
uuid:ad109203-7cbd-4185-a5f6-42f71031d70b
- Deposit date:
- 2018-04-03
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Terms of use
- Copyright date:
- 2018
- Licence:
- ORA Terms and conditions
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