Dataset icon

Dataset

Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package

Version:
1

Actions


Access Document


Files:

Authors/Creators


More by this author/creator
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Creator, Researcher

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Principal Investigator (PI)
Role:
Researcher
Role:
Researcher
Role:
Researcher
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Researcher
Expand contributors...
Publisher:
University of Oxford
Publication date:
2018
Version number:
1
DOI:
Keywords:
Subjects:
Documentation:
A description of the materials and methods is included within the TEP datasheet. This work provides the early tools to develop substrate reduction inhibitors for a genetic childhood seizure disorder, with the hypothesis to target the enzyme (AASS) upstream of the defective gene (ALDH7A1) in the human lysine metabolic pathway. This TEP package includes recombinant human AASS purification protocols, structures of the AASS second domain in different states, in vitro assays to detect ligand bindi... Expand documentation
UUID:
uuid:ad109203-7cbd-4185-a5f6-42f71031d70b
Deposit date:
2018-04-03

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP