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Reverse immunodynamics: a new method for identifying targets of protective immunity

Abstract:

Despite a dramatic increase in our ability to catalogue variation among pathogen genomes, we have made far fewer advances in using this information to identify targets of protective immunity. Epidemiological models predict that strong immune selection can cause antigenic variants to structure into genetically discordant sets of antigenic types (e.g. serotypes). A corollary of this theory is that targets of immunity may be identified by searching for non-overlapping associations of amino acids...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-018-37288-x

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Oxford college:
St Catherine's College
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
9
Article number:
2164
Publication date:
2019-02-15
Acceptance date:
2018-11-20
DOI:
EISSN:
2045-2322
Source identifiers:
944875
Pubs id:
pubs:944875
UUID:
uuid:ada100f1-02ce-4159-86d2-b5d9a5d06511
Local pid:
pubs:944875
Deposit date:
2018-11-21

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