Journal article
Whole-genome sequencing identifies homozygous BRCA2 deletion guiding treatment in dedifferentiated prostate cancer
- Abstract:
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Whole-genome sequencing (WGS) has transformed the understanding of the genetic drivers of cancer and is increasingly being used in cancer medicine to identify personalized therapies. Here we describe a case in which the application of WGS identified a tumoral BRCA2 deletion in a patient with aggressive dedifferentiated prostate cancer that was repeat-biopsied after disease progression. This would not have been detected by standard BRCA testing, and it led to additional treatment with a mainte...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.3MB)
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- Publisher copy:
- 10.1101/mcs.a001362
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Authors
Funding
+ National Institute for Health Research
More from this funder
Funding agency for:
Fairfax, B
Grant:
Intermediate Clinical Fellow (201488/Z/16/Z)
+ Wellcome
Trust
More from this funder
Funding agency for:
Fairfax, B
Grant:
Intermediate Clinical Fellow (201488/Z/16/Z)
Bibliographic Details
- Publisher:
- Cold Spring Harbor Laboratory Press Publisher's website
- Journal:
- Cold Spring Harbor Molecular Case Studies Journal website
- Volume:
- 3
- Issue:
- 3
- Article number:
- a001362
- Publication date:
- 2017-03-09
- Acceptance date:
- 2017-01-17
- DOI:
- EISSN:
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2373-2873
- ISSN:
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2373-2865
- Source identifiers:
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695509
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:695509
- UUID:
-
uuid:adae0080-1093-48f6-8846-219467c3613e
- Local pid:
- pubs:695509
- Deposit date:
- 2017-06-08
Terms of use
- Copyright holder:
- Purshouse et al
- Copyright date:
- 2017
- Notes:
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Copyright © 2017 Purshouse et al.; Published by Cold Spring Harbor Laboratory Press.
This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted reuse and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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