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Chapter One - Using evasins to target the chemokine network in inflammation

Abstract:

Inflammation, is driven by a network comprising cytokines, chemokines, their target receptors and leukocytes, and is a major pathologic mechanism that adversely affects organ function in diverse human diseases. Despite being supported by substantial target validation, no successful anti-chemokine therapeutic to treat inflammatory disease has yet been developed. This is in part because of the robustness of the chemokine network, which emerges from a large total chemokine load in disease, promi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Strategic
Oxford college:
Green Templeton College
Role:
Author
ORCID:
0000-0002-5571-0478
Publisher:
Elsevier Publisher's website
Pages:
1-38
Series:
Advances in Protein Chemistry and Structural Biology
Series number:
119
Publication date:
2019-11-26
Acceptance date:
2019-08-30
DOI:
EISSN:
1876-1631
ISSN:
1876-1623
Source identifiers:
1079630
ISBN:
9780128168448
Language:
English
Keywords:
Pubs id:
pubs:1079630
UUID:
uuid:adc08fd4-783d-450b-aad8-aeaecc8d4a75
Local pid:
pubs:1079630
Deposit date:
2020-01-16

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